We aim to have new scientific findings by developing statistical methods to summarize information from data and prior knowledege. Currently, we mainly focus on developing new statistical methods for (1) biological multi-omics data, such as (sc)RNA-seq, chip-seq, xWAS etc. to explore the mechanism underlying the complex phenotypes such as agronomic traits, diseases, tumors etc.; and (2) multimodal data including time series data, spatial data, network data etc. to integrate information from multiple dimensions to explore key features related to response.

Research Interests

Selected Publications

Present by Year (* corresponding author(s), # equal contribution, and authors with underline are (joint) students)

Algorithms for Feature Learning

  1. Regularized estimation of Matrix-variate autoregressive models. H. Jiang, B. Shen, Y. Li, Z. Gao*. Submitted.
  2. UK BioCoin: Swift Trait-Specific Summary Statistics Regression for UK Biobank. J. He#, G. Q#, …., H. Jiang*, G. Chen*. Submitted. (Homepage for UKC)
  3. Case-specific selection of batch correction methods for integrating single-cell transcriptomic data from different sources. X. Hu, …., J. Qian*, H. Jiang*. Submitted. (R package of RBET, Homepage for RBET).
  4. CS-GAN: Commonality-Specificity Attention GAN for Weakly Supervised Medical Lesion Segmentation. G. Su, X. Zhao, J. Yin*, H. Jiang*. Submitted.
  5. Bayesian Spatial-temporal Model for Detecting Alterations in Resting-State Functional Brain Network of Heavy Smokers, J. Hu, S. Chen, Z. Ye, F. Lin* and H.Jiang*. Submitted.
  6. H. Jiang#, J. Su#, Z. Ren, D. Wang, A. Hills, R. Kinoshita, M. R. Blatt, Y. Wang*, Y. Wang* (2024). Dual function of overexpressing plasma membrane H+-ATPase in balancing carbon-water use. Science Advances.
  7. Mengting Shao#, Min Tian#, Kaiyang Chen#, H.Jiang#,…., Chen Cao*, Ning Gu* (2024). Leveraging Random Effects in Cistrome-Wide Association Studies for Decoding the Genetic Determinants of Prostate Cancer. Advanced Science.
  8. C. Cao*, …., H.Jiang, G. Wang*, Q. Zhou* (2023). RAVAR: a curated repository for rare variant-trait associations. Nucleic Acids Research.
  9. H.Jiang, H. Li, Wing H. Wong* and X. Fan* (2022). Revealing Free Energy Landscape from MD Data via Conditional Angle Partition Tree. IEEE/ACM Transactions on Computational Biology and Bioinformatics. (code, data, Supp)
  10. M. Xu, Y. Chen, Z. Xu, L. Zhang*, H.Jiang*, C. Pian* (2022). MiRLoc: predicting miRNA subcellular localizaition by incorporating miRNA-mRNA interaction and mRNA subcelluar localizaition. Briefings in Bioinformatics.
  11. H.Jiang, Xingqiu Zhao, Ronald C.W. Ma and X.Fan* (2022). Consistent Screening Procedures in High-dimensional Binary Classification. Statistica Sinica.
  12. H. Li#, H.X. Zhang# and H.Jiang* (2021). Combining Power of Different Methods to Detect Associations in Large Data Sets. Briefings in Bioinformatics. (R package)
  13. Z. Li#, H.Jiang#, L. Kong, Y. Chen, K. Lang, X. Fan, L. Zhang* and C. Pian* (2021). Deep6mA: a deep learning framework explores similar patterns in DNA N6-methyladenine sites across different species. PLoS Computational Biology.
  14. H.Jiang and X. Fan* (2021). The Two-step Clustering Approach for Metastable States Learning. International Journal of Molecular Sciences.
  15. Y. Chen#, C. Kwok#, H.Jiang* and X.Fan* (2020). Detect Differentially Methylated Regions Using Non-homogeneous Hidden Markov Model for Bisulfite Sequencing Data. Methods. (code)
  16. H.Jiang and X.Fan* (2020). A Consistent Variable Screening Procedure with Family-wise Error Control. Journal of Statistical Computation and Simulation.
  17. H.Jiang and Q.Wu* (2018). Robust dependence measure for detecting associations in large data set. Acta Mathematica Scientia.
  18. H.Jiang, Y.Shan and Q.Wu (2017). Dependece Measure: A comparative study. Acta Mathematica Scientia.
  19. Q.Tan, H.Jiang* and Y.Ding (2014). Model Selection Based on Maximal Information Coefficient of Residuals. Acta Mathematica Scientia.

Applications to Plants

  1. H. Jiang#, J. Su#, Z. Ren, D. Wang, A. Hills, R. Kinoshita, M. R. Blatt, Y. Wang*, Y. Wang* (2024). Dual function of overexpressing plasma membrane H+-ATPase in balancing carbon-water use. Science Advances.
  2. M. Rui, ….,Z. Chen, D. Tissue, H.Jiang*, Y. Wang* (2024). Guard Cell and Subsidiary Cell Sizes are Key Determinants for Stomatal Kinetics and Drought Adaptation in Cereal Crops. New Phytologist. (News)
  3. Q. Den, H. Jiang, J. Hu, R. Pan (2024). Identification of auxiliary organellar targeting signals for plant peroxisomes using bioinformatic analysis of large protein sequence datasets followed by experimental validation. Photorespiration: Methods and Protocols. (BookChapter)
  4. X. Feng#, Z. Yu#, H. Fang, H.Jiang, ….., Y. He*, F. Liu* (2023). Plantorganelle Hunter is an effective deep-learning-based method for plant organelle phenotyping in electron microscopy. Nature Plants.
  5. J. Wang, X. Gu, …, H.Jiang, B. Zheng, Y. Chen*, Y. He* (2023). Advances in the endogenous and exogenous regulation of anthocyanins–the key to color change in eudicots. Critical Reviews in Plant Sciences.
  6. Q. Sun, ….., H.Jiang, D. Yan, B. Zheng, Y. He* (2023). Transcriptome Analysis Reveals the Response Mechanism of Digitaria sanguinalis, Arabidopsis thaliana and Poa annua under 4,8-Dihydroxy-1-tetralone Treatment. Plants.
  7. S. Qin,….., H.Jiang, …., B. Zheng, Y. He* (2023). Comparative Microscopic, Transcriptome and IAA Content Analyses Reveal the Stem Growth Variations in Two Cultivars Ilex verticillata. Plants.
  8. Q. Deng#, H. Li#, Y. Feng#, R. Xu, W. Li, R. Zhu, D. Akhter, X. Shen, J. Hu*, H.Jiang*, R. Pan* (2022). Defining upstream enhancing and inhibiting sequence patterns for plant Peroxisome Targeting Signal type 1 using large-scale in silico and in vivo analyses. The Plant Journal. (News)
  9. M. Rui, Y. Jing, H. Jiang*, Y. Wang* (2022). Quantitative System Modelling Bridges the Gap between Macro- and Microscopic Stomatal Model. Advanced Biology.

Applications to Medicine

  1. Long-term barely diet alleviates cognitive deficits in AD mice via regulating gut microbiome composition. Y. Hao#, Yu. Li#,…., H. Jiang*, Y. Wang*, S. Hao*. Submitted.
  2. Liquid-liquid phase separation-mediated regulation for the A-factor responsive quorum-sensing pathway in Streptomyces. B. Ma#, X. Hu#, C. Sun#, …, H. Jiang*, Q. Zhao*, X. Mao*. Submitted.
  3. Lactobacillus rhamnosus improves lifestyle intervention response in Gestational Diabetes Mellitus impeded by Gut Bacterium Bilophila wadsworthia. G. Ye, …., H. Jiang*, Q. Luo*. Submitted.
  4. Q. Ye#, Y. Li#, H. Liu#, J. Mao*, H.Jiang* (2023). Machine learning models for predicting steroid⁃resistant nephrotic syndrome. Frontiers in Immunology. (Webtool)
  5. H. Lei#, H. Jiang#, N. Zhang, T. Chen, L. Yang, D. Wang and Y. Shu* (2021). Increased urbanization reduced the effectiveness of school closures on seasonal influenza epidemics in China. Infectious Diseases of Poverty. (News)

Applications to other areas

  1. Jiwei Chen, Cheng Qian, Yuexuan Shu, Kourosh Salehi-Ashtiani, Jin Shang, H. Jiang*, Weiqi Fu* (2024). Bioinspired cell silicification of the model diatom Phaeodactylum tricornutum and its effects on cell metabolism. Sustainable Horizons.
  2. J. Chen, Y. Huang, Y. Shu, X. Hu, D. Wu, H. Jiang, K. Wang, W. Liu and W. Fu* (2022). Recent progress on systems and synthetic biology of diatoms for improving algal productivity. Frontiers in Bioengineering and Biotechnology.
  3. H.Jiang, H.-b. Li* and X.Fan* (2020). Bayesian Revisit of the Relationship between the Total Field Strength and the Volume Density of Interstellar Clouds. The Astrophysical Journal.
  4. H.-B. Li*, H.Jiang (in charge of statistical analysis), X.Fan, Q. Gu and Y. Zhang (2017). The Link between Magnetic-field Orientations and Star Formation Rates. Nature Astronomy. (Cover Paper, News)

Manuscripts

  1. Non-parametric GWAS: Another View on Genome-wide Association Study. X. Hu#, S. Yu# and H.Jiang*. [Preprint]
  2. Recent Advances on Phytohormone Regulation of Floral Bud Differentiation. X. Xie, S. Fu, L. Huang, S. Qin, J. Wang, Q. Sun, X. Wang, H. Yuan, D. Yan, Y. Wang, X. Mo, H. Wang, D. Xue, H. Jiang, J. Pozueta-Romero, B. Zheng, Y. He*.
  3. Non-parametric Gene-Enviroment interaction Detection, H.Jiang and X.Fan
  4. A Goodness-of-Fit Test for Statistical Models, H.Jiang. [Preprint]
  5. Bayesian Variable Selection for Single Index Logistic Model, Y. Sun and H.Jiang*. [Preprint]
  6. Parameter Estimation in Noisy Dynamical System, H.Jiang, and D.H., He
  7. Equitablity of Dependence Measure, H.Jiang, K.Liu and Y.Ding (2013). [Preprint]